Richard B. Kim, MD, FRCPC, Division Chair
Dr. Kim received his medical degree from University of Saskatchewan, Canada in 1987. After completing an internship and residency training at Royal University hospital in Saskatoon Canada in 1991, he went on to carry out postdoctoral fellowship training in Clinical Pharmacology at Vanderbilt University.
In 1994, upon completion of his fellowship training, he remained at Vanderbilt Clinical Pharmacology as a faculty member until 2006. He is currently Professor and Chair of the Division of Clinical Pharmacology in the Department of Medicine at the University of Western Ontario in London, Canada. His research interest is that of understanding the molecular basis of interindividual differences in drug disposition and the application of such finding to the emerging field of Personalized Medicine.
Research areas under active investigation in his laboratory include that of drug transporters, CYP enzymes, and the pathways involved in the regulated expression of such proteins. He is a member of ASCPT, ISSX, and AAPS. He is an editor for the Medical Letter Handbook of Adverse Drug Interactions, and an associate editor for Molecular Pharmacology. He is a fellow of AAPS, and member of the American Society for Clinical Investigation (ASCI).

Publications
2000  2001  2002  2003  2004
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Dresser G.K., Bailey D.G., Leake B.F., Schwarz U.I., Dawson P.A., Freeman D.J., and Kim R.B.: Fruit juices inhibit intestinal organic anion transporting polypeptide-mediated drug uptake to decrease fexofenadine oral availability in humans. Clin Pharmacol. Ther., 71:11-20, 2002. [Pubmed]

Ekins S., Kim R.B., Leake B.F., Dantzig A.H., Schuetz E.G., Lan L.B., Yasuda K., Shepard R.L., Winter M.A., Schuetz J.D., Wikel J.H., and Wrighton S.A.: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol. Pharmacol., 61:964-973, 2002.  [Pubmed]

Ekins S., Kim R.B., Leake B.F., Dantzig A.H., Schuetz E.G., Lan LB, Yasuda K., Shepard R.L., Winter M.A., Schuetz J.D., Wikel J.H., and Wrighton S.A.: Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates. Mol. Pharmacol., 61:974-981, 2002.  [Pubmed]

Illmer T., Schuler U.S., Thiede C., Schwarz U.I., Kim R.B., Gotthard S., Freund D., Schakel U., Ehninger G., and Schaich M.: MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients. Cancer Res., 62:4955-4962, 2002. [Pubmed]

Kanki H., Xie X.G., Kim R.B., George A.L., and Roden D.M.: Polymorphisms in beta-adrenergic receptor genes in the acquired long QT syndrome. J. Cardiovasc Electrophysiol., 13:252-256, 2002. [Pubmed]

Kim R.B.: Drugs as P-glycoprotein substrates, inhibitors, and inducers. Drug Metab. Rev., 34:47-54, 2002. [Pubmed]

Kim R.B.: MDR1 single nucleotide polymorphisms: Multiplicity of haplotypes and functional consequences. Pharmacogenetics., 12:425-427, 2002. [Pubmed]

Kim R.B.: Transporters and xenobiotic disposition. Toxicology, 181:291-297, 2002. [Pubmed]

Meng L.J., Wang P., Wolkoff A.W., Kim R.B., Tirona R.G., Hofmann A.F., and Pang K.S.: Transport of the sulfated, amidated bile acid sulfolithocholytaurine (SLCT) into isolated rat hepatocytes is mediated by Oatp1 and Oatp2. Hepatology, 35:1031-1040, 2002. [Pubmed]

Merino G., Alvarez A.I., Prieto J.G., and Kim R.B.: The antihelminthic agent albendazole does not interact with P-glycoprotein. Drug. Met. Disp., 30:365-369, 2002. [Pubmed]

Schuetz E.G., Lan L., Kim R.B., Kocarek T., Schuetz J.D., and Strom S.: Development of a real-time in vivo transcription assay: Application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents. Mol. Pharmacol., 61:439-445, 2002. [Pubmed]

Tirona R.G. and Kim R.B.: Pharmacogenomics of organic anion-transporting polypeptides (OATP). Adv. Drug Del. Rev., 54:1343-1352, 2002. [Pubmed]

Wandel C., Kim R.B., Wood M., Wood A.J.J.: Interaction between morphine, fentanyl, sufentanyl, alfentanil, loperamide and the drug efflux transporter P-glycoprotein. Anesthesiology, 96:913-920, 2002. [Pubmed]

Xie H-G., Prasad H.C., Kim R.B., and Stein C.M.: CYP2C9 allelic variants: ethnic distribution and functional significance. Adv. Drug Del. Rev., 54:1257-1270, 2002. [Pubmed]