Richard B. Kim, MD, FRCPC, Division Chair
Dr. Kim received his medical degree from University of Saskatchewan, Canada in 1987. After completing an internship and residency training at Royal University hospital in Saskatoon Canada in 1991, he went on to carry out postdoctoral fellowship training in Clinical Pharmacology at Vanderbilt University.
In 1994, upon completion of his fellowship training, he remained at Vanderbilt Clinical Pharmacology as a faculty member until 2006. He is currently Professor and Chair of the Division of Clinical Pharmacology in the Department of Medicine at the University of Western Ontario in London, Canada. His research interest is that of understanding the molecular basis of interindividual differences in drug disposition and the application of such finding to the emerging field of Personalized Medicine.
Research areas under active investigation in his laboratory include that of drug transporters, CYP enzymes, and the pathways involved in the regulated expression of such proteins. He is a member of ASCPT, ISSX, and AAPS. He is an editor for the Medical Letter Handbook of Adverse Drug Interactions, and an associate editor for Molecular Pharmacology. He is a fellow of AAPS, and member of the American Society for Clinical Investigation (ASCI).

Publications
2000  2001  2002  2003  2004
<<<        >>>

Dickmann L.J., Rettie A.E., Kneller M.B., Kim R.B., Wood A.J.J., Stein C.M., Wilkinson G.R., and Schwarz U.I.: Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans. Mol. Pharmacol., 60:317-323, 2001. [Pubmed]

Dishy V., Sofowora G.G., Xie H.G., Kim R.B., Byrne D.W., Stein C.M., and Wood A.J.J.: The effect of common polymorphisms of the Ã?2-adrenergic receptor on agonist-mediated vascular desensitization. N. Engl. J. Med., 345:1030-1035, 2001.  [Pubmed]

Jisaka M., Boeglin W.E., Kim R.B., and Brash A.R.: Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: Retention of catalytic activity on mutation of Serine-558 to asparagine, histidine, or alanine. Arch Biochem Biophys., 386:136-142, 2001. [Pubmed]

Kim R.B., Leake B.F., Choo E.F., Dresser G.K., Kubba S.V., Schwarz U.I., Taylor A., Xie H.G., McKinsey J., Zhou S., Lan L.B., Schuetz J.D., Schuetz E.G., and Wilkinson G.R.: Identification of functionally variant MDR1 alleles among European- and African-Americans. Clin. Pharmacol. Ther., 70:189-199, 2001.  [Pubmed]

Schuetz E.G., Strom S., Yasuda K., Lecureur V., Assem M., Brimer C., Lamba J., Kim R.B., Ramchandran V., Komoroski B.J., Venktaramanan R., Cai H., Sinal C.J., Gonzalez F.J., and Schuetz J.D.: Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters and cytochrome P450. J. Biol. Chem., 276:39411-39418, 2001.  [Pubmed]

Sofowora G., Dishy V., Xie H.G., Imamura H., Nishimi Y., Morales C.R., Morrow J.D., Kim R.B., Stein C.M., and Wood A.J.J: In vivo effects of Glu298Asp endothelial nitric oxide synthase polymorphism. Pharmacogenetics, 11:809-814, 2001. [Pubmed]

Stein C.M., Sadeque A.J., Murray J.J., Wandel C., Kim R.B., and Wood A.J.J.: Cyclosporine pharmacokinetics and pharmacodynamics in African American and white subjects. Clin. Pharmacol. Ther., 69:317-23, 2001.  [Pubmed]

Tirona R.G., Leake B.F., Merino G., and Kim R.B.: Polymorphisms in OATP-C: Identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. J. Biol. Chem., 276:35669-35675, 2001.  [Pubmed]

Xie H.G., Dishy V., Sofowora G., Kim R.B., Landau R., Smiley R.M., Zhou H.H., Wood A.J.J., Harris P., and Stein C.M.: Arg390Gly Ã?1-adrenoceptor polymorphism varies in frequency among different ethnic groups but does not alter response in vivo. Pharmacogenetics, 11:191-197, 2001. [Pubmed]

Xie H.G., Kim R.B., Wood A.J.J., Stein C.M.: Molecular basis of ethnic differences in drug disposition and response. Annu. Rev. Pharmacol. Toxicol., 41:815-850, 2001. [Pubmed]

Zhang J., Huelh P., Green E., Toudhman J., Watkins P., Daly A., Hall S.D., Maurel P., Relling M., Brimer C., Yasuda K., Hancock M., Kim R.B., Strom S., Thummel K., Russel C., Schuetz E.G., and Boguski M.S.: The human pregnane X receptor: Genomic structure and identification and functional characterization of natural allelic variants., Pharmacogenetics, 11:555-572, 2001. [Pubmed]